Although a close relationship exists among raised liver fat levels, insulin resistance, and raised liver enzyme levels (52), high levels of liver fat are not inevitably associated with hepatic insulin resistance. This is analogous to the discordance observed in the muscle of trained athletes in whom raised intramyocellular triacylglycerol is associated with high insulin sensitivity (53). This relationship is also seen in muscle of mice overexpressing the enzyme DGAT-1, which rapidly esterifies diacylglycerol to metabolically inert triacylglycerol (54). In both circumstances, raised intracellular triacylglycerol stores coexist with normal insulin sensitivity. When a variant of PNPLA3 was described as determining increased hepatic fat levels, it appeared that a major factor underlying nonalcoholic fatty liver disease and insulin resistance was identified (55). However, this relatively rare genetic variant is not associated with hepatic insulin resistance (56). Because the responsible G allele of PNPLA3 is believed to code for a lipase that is ineffective in triacylglycerol hydrolysis, it appears that diacylglycerol and fatty acids are sequestered as inert triacylglycerol, preventing any inhibitory effect on insulin signaling.
Genetic variations likely act together with health and lifestyle factors to influence an individual's overall risk of type 2 diabetes. All of these factors are related, directly or indirectly, to the body's ability to produce and respond to insulin. Health conditions that predispose to the disease include overweight or obesity, insulin resistance, prediabetes (higher-than-normal blood sugar levels that do not reach the cutoff for diabetes), and a form of diabetes called gestational diabetes that occurs during pregnancy. Lifestyle factors including smoking, a poor diet, and physical inactivity also increase the risk of type 2 diabetes.
Track3 Diabetes Tracker & Logbook App tracks an impressive number of health factors for people with diabetes, including food, blood glucose, insulin, medications, exercise and weight. Food tracking can be done out of a built-in database, or users can program their own foods and create shortcuts for quick inputs. When the user works out, they can enter calories burned right from a cardio machine or estimate them for a workout. Tracking metrics can be displayed on multiple mobile devices or on the web.
One of the key factors in Joslin’s treatment of diabetes is tight blood glucose control, so be certain that your treatment helps get your blood glucose readings as close to normal as safely possible. Patients should discuss with their doctors what their target blood glucose range is. It is also important to determine what your goal is for A1C readings (a test that determines how well your diabetes is controlled over the past 2-3 months). By maintaining blood glucose in the desired range, you’ll likely avoid many of the complications some people with diabetes face.
In fact, high blood pressure is very common with diabetes, as two in three adults with diabetes also have high blood pressure, according to the American Diabetes Association (ADA). High blood pressure doesn't always have noticeable symptoms and you may not know you have it unless your doctor checks. Still, it can lead to serious complications including heart attack, stroke, eye problems, and kidney disease.
American Indian/Alaska Native. American Indian/Alaska Native women have the highest rate of diabetes among all racial and ethnic groups in the United States. It is more than twice as common for American Indian/Alaska Native women to be diagnosed with diabetes compared to white women. But rates of diabetes are different in different regions of the United States. Rates are lowest in Alaska Native people and highest in people who are American Indian and live in certain areas of the Southwest.1
^ Jump up to: a b Picot J, Jones J, Colquitt JL, Gospodarevskaya E, Loveman E, Baxter L, Clegg AJ (September 2009). "The clinical effectiveness and cost-effectiveness of bariatric (weight loss) surgery for obesity: a systematic review and economic evaluation". Health Technology Assessment. 13 (41): 1–190, 215–357, iii–iv. doi:10.3310/hta13410. PMID 19726018.
Designed for smartphones and tablets this application is intended to help diabetics to manage better their diabetes and keep it under control. Users can log their values in the logbook and keep the records with them all the time. The application tracks almost all aspects of the diabetes treatment and provides detailed reports, charts, and statistics to share via email with the supervising specialists. It provides various tools to the diabetics, so they can find the trends in blood glucose levels and allows them to calculate normal and prolonged insulin boluses using its highly effective, top-notch bolus calculator.
The connection may be hard to imagine. But the primary reason that regularly skimping on shuteye can increase your risk of type 2 diabetes is because your hormone levels get thrown out of whack. Specifically, with ongoing sleep loss, less insulin (a hormone that regulates blood sugar) is released in the body after you eat. Meanwhile, your body secretes more stress hormones (such as cortisol), which helps you stay awake but makes it harder for insulin to do its job effectively. The net effect: Too much glucose stays in the bloodstream, which can increase your risk of developing type 2 diabetes.
Type 1 diabetes is partly inherited, with multiple genes, including certain HLA genotypes, known to influence the risk of diabetes. In genetically susceptible people, the onset of diabetes can be triggered by one or more environmental factors, such as a viral infection or diet. Several viruses have been implicated, but to date there is no stringent evidence to support this hypothesis in humans. Among dietary factors, data suggest that gliadin (a protein present in gluten) may play a role in the development of type 1 diabetes, but the mechanism is not fully understood.
Meanwhile the ADA, in their most recent update on the Standards of Medical Care in Diabetes, have lifted the restriction on sodium in the diet of those with diabetes. This brings the recommended daily levels of sodium for people with diabetes in line with the general population at 2,300 milligrams (mg) per day. They also acknowledge that there is not a single diet that fits all people with diabetes.
“We usually see patients quarterly for appointments, which means the other 361 days of the year, they’re on their own,” says endocrinologist Amber Champion, MD, at Great Plains Health in North Platte, Nebraska. “They need to have the knowledge and tools to take care of themselves. Diabetes-related apps can be useful to help keep track of all the data and see it visually. They can also help educate and teach patients to spot trends and keep their data organized.”
You are more likely to develop type 2 diabetes if you are not physically active and are overweight or obese. Extra weight sometimes causes insulin resistance and is common in people with type 2 diabetes. The location of body fat also makes a difference. Extra belly fat is linked to insulin resistance, type 2 diabetes, and heart and blood vessel disease. To see if your weight puts you at risk for type 2 diabetes, check out these Body Mass Index (BMI) charts.
Disclaimer: The entire contents of this website are based upon the opinions of Dr. Mercola, unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Mercola and his community. Dr. Mercola encourages you to make your own health care decisions based upon your research and in partnership with a qualified health care professional. If you are pregnant, nursing, taking medication, or have a medical condition, consult your health care professional before using products based on this content.
The mySugr logbook app is an easy and complete diabetes tracker. Log and monitor your daily blood sugar level, record your insulin, use the app to track your carbohydrate count, and make notes along the way. + Easy and personalized logging screen to enter information about your diet, medications, carbohydrate intake, meals, blood glucose levels that can be graphed. Motivating challenges and feedback to help cope with Type 1 and Type 2 diabetes. The app provides detailed reports that you can send to your doctor. mySugr Pro can be activated at no charge with some Accu-Chek® devices when ordered (for free) through mySugr or with a subscription.